Homeostatic Regulation of Neuronal Excitability
نویسندگان
چکیده
منابع مشابه
Stability of Neuronal Networks with Homeostatic Regulation
Neurons are equipped with homeostatic mechanisms that counteract long-term perturbations of their average activity and thereby keep neurons in a healthy and information-rich operating regime. While homeostasis is believed to be crucial for neural function, a systematic analysis of homeostatic control has largely been lacking. The analysis presented here analyses the necessary conditions for sta...
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Stability of neural circuits is reliant on homeostatic mechanisms that return neuron activity towards pre-determined and physiologically appropriate levels. Without these mechanisms, changes due to synaptic plasticity, ageing and disease may push neural circuits towards instability. Whilst widely documented, understanding of how and when neurons determine an appropriate activity level, the so-c...
متن کاملSupplementary Information: Stability of neuronal networks with homeostatic regulation
Here we 1) derive stability conditions for the network with a non-linear f/I curve, and 2) the tighter stability criterion which be obtained by considering only the slowest mode of the system. Qualitatively, for the 3-dimensional system a criterion exists based on the envelope of the non-linearity. For the full network, the criterion is based on the maximum slope of the non-linearity and this i...
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The hyperpolarization-activated cation current (Ih) plays an important role in determining membrane potential and firing characteristics of neurons and therefore is a potential target for regulation of intrinsic excitability. Here we show that an increase in AMPA-receptor-dependent synaptic activity induced by alpha-latrotoxin or glutamate application as well as direct depolarization results in...
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During development and learning, a neuron actively maintains a stable state of excitability by adjusting the strength of its synaptic inputs (Turrigiano and Nelson, 2004). This homeostatic synaptic plasticity ensures that a neuron maintains a set-point spike firing rate when the overall synaptic input is increasing or decreasing (Turrigiano, 2008). Beside this homeostatic synaptic plasticity, n...
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ژورنال
عنوان ژورنال: Scholarpedia
سال: 2013
ISSN: 1941-6016
DOI: 10.4249/scholarpedia.1656